Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation

Creatine (Cr), phosphocreatine (PCr), and creatine kinases (CK) comprise an energy shuttle linking ATP production in mitochondria with cellular consumption sites. Myocytes cannot synthesize Cr: these cells depend on uptake across the cell membrane by a specialized creatine transporter (CrT) to maint...

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Dettagli Bibliografici
Pubblicato in:Physiol Rep
Autori principali: Santacruz, Lucia, Arciniegas, Antonio Jose Luis, Darrabie, Marcus, Mantilla, Jose G., Baron, Rebecca M., Bowles, Dawn E., Mishra, Rajashree, Jacobs, Danny O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582266/
https://ncbi.nlm.nih.gov/pubmed/28821596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13382
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