Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation

Creatine (Cr), phosphocreatine (PCr), and creatine kinases (CK) comprise an energy shuttle linking ATP production in mitochondria with cellular consumption sites. Myocytes cannot synthesize Cr: these cells depend on uptake across the cell membrane by a specialized creatine transporter (CrT) to maint...

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Bibliographic Details
Published in:Physiol Rep
Main Authors: Santacruz, Lucia, Arciniegas, Antonio Jose Luis, Darrabie, Marcus, Mantilla, Jose G., Baron, Rebecca M., Bowles, Dawn E., Mishra, Rajashree, Jacobs, Danny O.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582266/
https://ncbi.nlm.nih.gov/pubmed/28821596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13382
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