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Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation
Creatine (Cr), phosphocreatine (PCr), and creatine kinases (CK) comprise an energy shuttle linking ATP production in mitochondria with cellular consumption sites. Myocytes cannot synthesize Cr: these cells depend on uptake across the cell membrane by a specialized creatine transporter (CrT) to maint...
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| Published in: | Physiol Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
John Wiley and Sons Inc.
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5582266/ https://ncbi.nlm.nih.gov/pubmed/28821596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13382 |
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