Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation

Creatine (Cr), phosphocreatine (PCr), and creatine kinases (CK) comprise an energy shuttle linking ATP production in mitochondria with cellular consumption sites. Myocytes cannot synthesize Cr: these cells depend on uptake across the cell membrane by a specialized creatine transporter (CrT) to maint...

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Publicado en:Physiol Rep
Autores principales: Santacruz, Lucia, Arciniegas, Antonio Jose Luis, Darrabie, Marcus, Mantilla, Jose G., Baron, Rebecca M., Bowles, Dawn E., Mishra, Rajashree, Jacobs, Danny O.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582266/
https://ncbi.nlm.nih.gov/pubmed/28821596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13382
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