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Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation
Creatine (Cr), phosphocreatine (PCr), and creatine kinases (CK) comprise an energy shuttle linking ATP production in mitochondria with cellular consumption sites. Myocytes cannot synthesize Cr: these cells depend on uptake across the cell membrane by a specialized creatine transporter (CrT) to maint...
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| Publicado en: | Physiol Rep |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5582266/ https://ncbi.nlm.nih.gov/pubmed/28821596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13382 |
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