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Paradoxical effect of IKKβ inhibition on the expression of E3 ubiquitin ligases and unloading‐induced skeletal muscle atrophy

We tested whether NF‐κB pathway is indispensable for the increase in expression of E3‐ligases and unloading‐induced muscle atrophy using IKKβ inhibitor IMD‐0354. Three groups of rats were used: nontreated control (C), 3 days of unloading/hindlimb suspension with (HS+IMD) or without (HS) IMD‐0354. Le...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Belova, Svetlana P., Shenkman, Boris S., Kostrominova, Tatiana Y., Nemirovskaya, Tatiana L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582258/
https://ncbi.nlm.nih.gov/pubmed/28839114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13291
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