Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18

The cytokine interleukin (IL)-18 is a crucial amplifier of natural killer (NK) cell function. IL-18 signaling is regulated by the inhibitory effects of IL-18 binding protein (IL-18BP). Using mice deficient in IL-18BP (IL-18BPKO), we investigated the impact of mismanaged IL-18 signaling on NK cells....

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Bibliografske podrobnosti
izdano v:Front Immunol
Main Authors: Harms, Robert Z., Creer, Austin J., Lorenzo-Arteaga, Kristina M., Ostlund, Katie R., Sarvetnick, Nora E.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581878/
https://ncbi.nlm.nih.gov/pubmed/28900426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01020
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