Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system in which most patients have serum autoantibodies (called NMO-IgG) that bind to astrocyte water channel aquaporin-4 (AQP4). A potential therapeutic strategy in NMO is to block the interaction of NMO-IgG...

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Vydáno v:Biochim Biophys Acta
Hlavní autoři: Alberga, Domenico, Trisciuzzi, Daniela, Lattanzi, Gianluca, Bennett, Jeffrey L., Verkman, Alan S., Mangiatordi, Giuseppe Felice, Nicolotti, Orazio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581535/
https://ncbi.nlm.nih.gov/pubmed/28477975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2017.05.001
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