Mutagenesis of the Aquaporin 4 Extracellular Domains Defines Restricted Binding Patterns of Pathogenic Neuromyelitis Optica IgG

Neuromyelitis optica-immunoglobulin G (NMO-IgG) binds to aquaporin-4 (AQP4) water channels in the central nervous system leading to immune-mediated injury. We have previously demonstrated that a high proportion of CSF plasma cells of NMO patients produce antibody to the extracellular domains of the...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Owens, Gregory P., Ritchie, Alanna, Rossi, Andrea, Schaller, Kristin, Wemlinger, Scott, Schumann, Hannah, Shearer, Andrew, Verkman, Alan S., Bennett, Jeffrey L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424347/
https://ncbi.nlm.nih.gov/pubmed/25792738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.647149
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