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Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements

PSI-BLAST is an iterative program to search a database for proteins with distant similarity to a query sequence. We investigated over a dozen modifications to the methods used in PSI-BLAST, with the goal of improving accuracy in finding true positive matches. To evaluate performance we used a set of...

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Bibliografiset tiedot
Päätekijät: Schäffer, Alejandro A., Aravind, L., Madden, Thomas L., Shavirin, Sergei, Spouge, John L., Wolf, Yuri I., Koonin, Eugene V., Altschul, Stephen F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2001
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC55814/
https://ncbi.nlm.nih.gov/pubmed/11452024
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