Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements

PSI-BLAST is an iterative program to search a database for proteins with distant similarity to a query sequence. We investigated over a dozen modifications to the methods used in PSI-BLAST, with the goal of improving accuracy in finding true positive matches. To evaluate performance we used a set of...

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Dades bibliogràfiques

Publicat a:	Nucleic Acids Res
Autors principals:	Schäffer, Alejandro A., Aravind, L., Madden, Thomas L., Shavirin, Sergei, Spouge, John L., Wolf, Yuri I., Koonin, Eugene V., Altschul, Stephen F.
Format:	Artigo
Idioma:	Inglês
Publicat:	Oxford University Press 2001
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55814/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11452024/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.14.2994
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