BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation

BRCA1-associated protein 1 (BAP1) is a potent tumor suppressor gene that modulates environmental carcinogenesis(1-3). All carriers of inherited heterozygous germline BAP1 inactivating mutations (BAP1(+/-)) developed one and often several BAP1(-/-) malignancies in their lifetime(4), mostly malignant...

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Publicado no:Nature
Principais autores: Bononi, Angela, Giorgi, Carlotta, Patergnani, Simone, Larson, David, Verbruggen, Kaitlyn, Tanji, Mika, Pellegrini, Laura, Signorato, Valentina, Olivetto, Federica, Pastorino, Sandra, Nasu, Masaki, Napolitano, Andrea, Gaudino, Giovanni, Morris, Paul, Sakamoto, Greg, Ferris, Laura K., Danese, Alberto, Raimondi, Andrea, Tacchetti, Carlo, Kuchay, Shafi, Pass, Harvey I., Affar, El Bachir, Yang, Haining, Pinton, Paolo, Carbone, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581194/
https://ncbi.nlm.nih.gov/pubmed/28614305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22798
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