Associations of α-thalassemia and BCL11A with stroke in Nigerian, United States, and United Kingdom sickle cell anemia cohorts

α-Thalassemia and the BCL11A rs1427407 T allele are commonly observed in sickle cell anemia (SCA) patients and are associated with reduced hemolysis and higher hemoglobin F levels, respectively. We investigated whether a high-risk genetic profile, defined as SCA patients who did not inherit either α...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Saraf, Santosh L., Akingbola, Titilola S., Shah, Binal N., Ezekekwu, Chinedu A., Sonubi, Omowunmi, Zhang, Xu, Hsu, Lewis L., Gladwin, Mark T., Machado, Roberto F., Cooper, Richard S., Gordeuk, Victor R., Tayo, Bamidele O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Global Advances
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580997/
https://ncbi.nlm.nih.gov/pubmed/28868518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017005231
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