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The Transcellular Propagation and Intracellular Trafficking of α-Synuclein

Parkinson’s disease is the second most common neurodegenerative disorder, with only partial symptomatic therapy and no mechanism-based therapies. The accumulation and aggregation of α-synuclein is causatively linked to the sporadic form of the disease, which accounts for 95% of cases. The pathology...

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Pubblicato in:Cold Spring Harb Perspect Med
Autori principali: Tofaris, George K., Goedert, Michel, Spillantini, Maria Grazia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580513/
https://ncbi.nlm.nih.gov/pubmed/27920026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a024380
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