Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome

Biogenesis of mammalian red blood cells requires nuclear expulsion by orthochromatic erythoblasts late in terminal differentiation (enucleation), but the mechanism is largely unexplained. Here, we employed high-resolution confocal microscopy to analyze nuclear morphology and F-actin rearrangements d...

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Bibliographic Details
Published in:Blood
Main Authors: Nowak, Roberta B., Papoin, Julien, Gokhin, David S., Casu, Carla, Rivella, Stefano, Lipton, Jeffrey M., Blanc, Lionel, Fowler, Velia M.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2017
Subjects:
Red Cells, Iron, and Erythropoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580276/
https://ncbi.nlm.nih.gov/pubmed/28729432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-787051
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