Nicotinamide mononucleotide inhibits post-ischemic NAD(+) degradation and dramatically ameliorates brain damage following global cerebral ischemia

Nicotinamide adenine dinucleotide (NAD(+)) is an essential cofactor for multiple cellular metabolic reactions and has a central role in energy production. Brain ischemia depletes NAD(+) pools leading to bioenergetics failure and cell death. Nicotinamide mononucleotide (NMN) is utilized by the NAD(+)...

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Publié dans:Neurobiol Dis
Auteurs principaux: Park, Ji H., Long, Aaron, Owens, Katrina, Kristian, Tibor
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580241/
https://ncbi.nlm.nih.gov/pubmed/27425894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.07.018
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