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CD38 Knockout Mice Show Significant Protection Against Ischemic Brain Damage Despite High Level Poly-ADP-Ribosylation
Several enzymes in cellular bioenergetics metabolism require NAD(+) as an essential cofactor for their activity. NAD(+) depletion following ischemic insult can result in cell death and has been associated with over-activation of poly-ADP-ribose polymerase PARP1 as well as an increase in NAD(+) consu...
Wedi'i Gadw mewn:
Cyhoeddwyd yn: | Neurochem Res |
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Prif Awduron: | , , , , , |
Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
2016
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5580240/ https://ncbi.nlm.nih.gov/pubmed/27518087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-016-2031-9 |
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