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Down-regulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells
We previously identified serine protease HtrA1 as a down-regulated gene in epithelial ovarian cancer (EOC), but the functional consequence of loss of HtrA1 in EOC remains largely unclear. Here, we report that loss of HtrA1 attenuates anoikis - a critical physiological barrier for tumor metastasis. I...
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| Pubblicato in: | Cancer Res |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5579484/ https://ncbi.nlm.nih.gov/pubmed/20388781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3557 |
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