A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors

Cyclooxygenase-2 inhibitors (coxibs) are characterized by multiple molecular off-target effects and increased coronary artery disease (CAD) risk. Here, we systematically explored common variants of genes representing molecular targets of coxibs for association with CAD. Given a broad spectrum of ple...

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書誌詳細
出版年:Sci Rep
主要な著者: Brænne, Ingrid, Willenborg, Christina, Tragante, Vinicius, Kessler, Thorsten, Zeng, Lingyao, Reiz, Benedikt, Kleinecke, Mariana, von Ameln, Simon, Willer, Cristen J., Laakso, Markku, Wild, Philipp S., Zeller, Tanja, Wallentin, Lars, Franks, Paul W., Salomaa, Veikko, Dehghan, Abbas, Meitinger, Thomas, Samani, Nilesh J., Asselbergs, Folkert W., Erdmann, Jeanette, Schunkert, Heribert
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579257/
https://ncbi.nlm.nih.gov/pubmed/28860667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10928-4
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