Neuroblastoma patient-derived xenograft cells cultured in stem-cell promoting medium retain tumorigenic and metastatic capacities but differentiate in serum

Cultured cancer cells serve as important models for preclinical testing of anti-cancer compounds. However, the optimal conditions for retaining original tumor features during in vitro culturing of cancer cells have not been investigated in detail. Here we show that serum-free conditions are critical...

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Pubblicato in:Sci Rep
Autori principali: Persson, Camilla U., von Stedingk, Kristoffer, Bexell, Daniel, Merselius, My, Braekeveldt, Noémie, Gisselsson, David, Arsenian-Henriksson, Marie, Påhlman, Sven, Wigerup, Caroline
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579187/
https://ncbi.nlm.nih.gov/pubmed/28860499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09662-8
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