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SIRT6 promotes osteogenic differentiation of mesenchymal stem cells through BMP signaling
SIRT6 has been identified as an H3K9 deacetylase and a critical regulator of genome stability, telomere integrity, and metabolic homeostasis. Sirt6-deficient mice displayed dramatic phenotypes including profound lymphopenia, loss of subcutaneous fat, lordokyphosis and low bone marrow density. Here,...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5578964/ https://ncbi.nlm.nih.gov/pubmed/28860594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10323-z |
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