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Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import

Virtually all mitochondrial matrix proteins and a considerable number of inner membrane proteins carry a positively charged, N-terminal presequence and are imported by the TIM23 complex (presequence translocase) located in the inner mitochondrial membrane. The voltage-regulated Tim23 channel constit...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Denkert, Niels, Schendzielorz, Alexander Benjamin, Barbot, Mariam, Versemann, Lennart, Richter, Frank, Rehling, Peter, Meinecke, Michael
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578737/
https://ncbi.nlm.nih.gov/pubmed/28857742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28324
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