mlh3 mutations in baker’s yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide

Mlh1-Mlh3 is an endonuclease hypothesized to act in meiosis to resolve double Holliday junctions into crossovers. It also plays a minor role in eukaryotic DNA mismatch repair (MMR). To understand how Mlh1-Mlh3 functions in both meiosis and MMR, we analyzed in baker’s yeast 60 new mlh3 alleles. Five...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Al-Sweel, Najla, Raghavan, Vandana, Dutta, Abhishek, Ajith, V. P., Di Vietro, Luigi, Khondakar, Nabila, Manhart, Carol M., Surtees, Jennifer A., Nishant, K. T., Alani, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578695/
https://ncbi.nlm.nih.gov/pubmed/28827832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006974
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