Tissue Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

Tumor-associated macrophages (TAMs) are essential components of the cancer microenvironment and play critical roles in the regulation of tumor progression. Optimal therapeutic intervention requires in-depth understanding of the sources that sustain macrophages in malignant tissues. In this study, we...

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Gepubliceerd in:Immunity
Hoofdauteurs: Zhu, Yu, Herndon, John M., Sojka, Dorothy K., Kim, Ki-Wook, Knolhoff, Brett L., Zuo, Chong, Cullinan, Darren R., Luo, Jingqin, Bearden, Audrey R., Lavine, Kory J., Yokoyama, Wayne M., Hawkins, William G., Fields, Ryan C., Randolph, Gwendalyn J., DeNardo, David G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578409/
https://ncbi.nlm.nih.gov/pubmed/28813661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.07.014
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