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Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines

Therapeutic efficacy of cisplatin-based chemotherapy for advanced-stage urothelial carcinoma (UC) is limited by drug resistance. The nuclear factor (erythroid-derived 2)-like 2 (NRF2) pathway is a major regulator of cytoprotective responses. We investigated its involvement in cisplatin resistance in...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Skowron, Margaretha A., Niegisch, Günter, Albrecht, Philipp, van Koeveringe, Gommert, Romano, Andrea, Albers, Peter, Schulz, Wolfgang A., Hoffmann, Michèle J.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578070/
https://ncbi.nlm.nih.gov/pubmed/28767070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18081680
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