Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines

The DNA-damaging compound cisplatin is broadly employed for cancer chemotherapy. The mutagenic effects of cisplatin on cancer cell genomes are poorly studied and might even contribute to drug resistance. We have therefore analyzed mutations and chromosomal alterations in four cisplatin-resistant bla...

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Vydáno v:Sci Rep
Hlavní autoři: Skowron, Margaretha A., Petzsch, Patrick, Hardt, Karin, Wagner, Nicholas, Beier, Manfred, Stepanow, Stefanie, Drechsler, Matthias, Rieder, Harald, Köhrer, Karl, Niegisch, Günter, Hoffmann, Michèle J., Schulz, Wolfgang A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785536/
https://ncbi.nlm.nih.gov/pubmed/31597922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50891-w
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