A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.

Amplifications of two oncogenes, c-K-ras-2 and c-myc, were found in a human lung giant cell carcinoma (LGCC) Lu-65, which is maintained in nude mice. The extent of c-K-ras-2 and myc amplifications were estimated to be 10- and 8-fold, respectively, by means of the Southern hybridization procedure. In...

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Publicat a:EMBO J
Autors principals: Taya, Y, Hosogai, K, Hirohashi, S, Shimosato, Y, Tsuchiya, R, Tsuchida, N, Fushimi, M, Sekiya, T, Nishimura, S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1984
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC557793/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6098458/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1984.tb02236.x
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