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Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient.

The transforming gene of malignant melanoma tissue obtained from a Japanese patient and maintained in nude mice has been cloned in its biologically active form and identified as the c-Ha-ras-1 gene, a homologue of the viral Ha-ras gene. Nucleotide sequence analysis revealed that the genetic alterati...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Sekiya, T, Fushimi, M, Hori, H, Hirohashi, S, Nishimura, S, Sugimura, T
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1984
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391572/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6087347/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.15.4771
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