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Precarious maintenance of simple DNA repeats in eukaryotes
In this review, we discuss how two evolutionarily conserved pathways at the interface of DNA replication and repair, template switching and break-induced replication, lead to the deleterious large-scale expansion of trinucleotide DNA repeats that cause numerous hereditary diseases. We highlight that...
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| Publicado no: | Bioessays |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5577815/ https://ncbi.nlm.nih.gov/pubmed/28703879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201700077 |
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