Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space

In previous studies, we have isolated several marine indole alkaloids and evaluated them in the forced swim test (FST) and locomotor activity test, revealing their potential as antidepressant and sedative drug leads. Amongst the reported metabolites to display such activities was 5-bromo-N,N-dimethy...

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Bibliographic Details
Published in:Mar Drugs
Main Authors: Ibrahim, Mohamed A., El-Alfy, Abir T., Ezel, Kelly, Radwan, Mohamed O., Shilabin, Abbas G., Kochanowska-Karamyan, Anna J., Abd-Alla, Howaida I., Otsuka, Masami, Hamann, Mark T.
Format: Artigo
Language:Inglês
Published: MDPI 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577603/
https://ncbi.nlm.nih.gov/pubmed/28792478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md15080248
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