Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space

In previous studies, we have isolated several marine indole alkaloids and evaluated them in the forced swim test (FST) and locomotor activity test, revealing their potential as antidepressant and sedative drug leads. Amongst the reported metabolites to display such activities was 5-bromo-N,N-dimethy...

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Pubblicato in:Mar Drugs
Autori principali: Ibrahim, Mohamed A., El-Alfy, Abir T., Ezel, Kelly, Radwan, Mohamed O., Shilabin, Abbas G., Kochanowska-Karamyan, Anna J., Abd-Alla, Howaida I., Otsuka, Masami, Hamann, Mark T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577603/
https://ncbi.nlm.nih.gov/pubmed/28792478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md15080248
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