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Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins

Spider gating modifier toxins (GMTs) are potent modulators of voltage-gated ion channels and have thus attracted attention as drug leads for several pathophysiological conditions. GMTs contain three disulfide bonds organized in an inhibitory cystine knot, which putatively confers them with high stab...

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Bibliografiske detaljer
Udgivet i:Toxins (Basel)
Main Authors: Agwa, Akello J., Huang, Yen-Hua, Craik, David J., Henriques, Sónia T., Schroeder, Christina I.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577582/
https://ncbi.nlm.nih.gov/pubmed/28805686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins9080248
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