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Ivermectin activates GIRK channels in a PIP(2)‐dependent, G(βγ)‐independent manner and an amino acid residue at the slide helix governs the activation
KEY POINTS: Ivermectin (IVM) is a widely used antiparasitic drug in humans and pets which activates glutamate‐gated Cl(−) channel in parasites. It is known that IVM binds to the transmembrane domains (TMs) of several ligand‐gated channels, such as Cys‐loop receptors and P2X receptors. We found that...
Gespeichert in:
| Veröffentlicht in: | J Physiol |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5577542/ https://ncbi.nlm.nih.gov/pubmed/28715108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP274871 |
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