Accumulation of H/ACA snoRNPs depends on the integrity of the conserved central domain of the RNA-binding protein Nhp2p

Box H/ACA small nucleolar ribonucleoprotein particles (H/ACA snoRNPs) play key roles in the synthesis of eukaryotic ribosomes. How box H/ACA snoRNPs are assembled remains unknown. Here we show that yeast Nhp2p, a core component of these particles, directly binds RNA. In vitro, Nhp2p interacts with h...

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Hauptverfasser: Henras, Anthony, Dez, Christophe, Noaillac-Depeyre, Jacqueline, Henry, Yves, Caizergues-Ferrer, Michèle
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2001
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC55775/
https://ncbi.nlm.nih.gov/pubmed/11433018
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