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Library siRNA-generating RNA nanosponges for gene silencing by complementary rolling circle transcription

Since the discovery of RNA interference (RNAi), small interfering RNA (siRNA) has been powerful tools for gene downregulation in biomedical applications. Despite the outstanding efficacy of siRNA, the development of a therapeutic delivery system remains a challenge owing to the instability of RNA. I...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Han, Sangwoo, Kim, Hyejin, Lee, Jong Bum
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577100/
https://ncbi.nlm.nih.gov/pubmed/28855687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10219-y
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