Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens

The malaria parasite Plasmodium falciparum and related apicomplexan pathogens contain an essential plastid organelle, the apicoplast, which is a key anti-parasitic target. Derived from secondary endosymbiosis, the apicoplast depends on novel, but largely cryptic, mechanisms for protein/lipid import...

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Vydáno v:eLife
Hlavní autoři: Amberg-Johnson, Katherine, Hari, Sanjay B, Ganesan, Suresh M, Lorenzi, Hernan A, Sauer, Robert T, Niles, Jacquin C, Yeh, Ellen
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576918/
https://ncbi.nlm.nih.gov/pubmed/28826494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29865
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