Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3′ end can be exported efficiently and specifically to the cytoplasm in mammalian cells

Hammerhead ribozymes were expressed under the control of similar tRNA promoters, localizing transcripts either in the cytoplasm or the nucleus. The tRNA(Val)-driven ribozyme (tRNA-Rz; tRNA with extra sequences at the 3′ end) that has been used in our ribozyme studies was exported efficiently into th...

Полное описание

Библиографические подробности

Опубликовано в::	Nucleic Acids Res
Главные авторы:	Kuwabara, Tomoko, Warashina, Masaki, Koseki, Shiori, Sano, Masayuki, Ohkawa, Jun, Nakayama, Kazuhisa, Taira, Kazunari
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Oxford University Press 2001
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55762/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11433023/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.13.2780
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