Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3′ end can be exported efficiently and specifically to the cytoplasm in mammalian cells

Lignende værker

• RNA–protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA
  af: Warashina, Masaki, et al.
  Udgivet: (2001)
• tRNA(Val)-heterodimeric maxizymes with high potential as geneinactivating agents: Simultaneous cleavage at two sites in HIV-1 tat mRNA in cultured cells
  af: Kuwabara, Tomoko, et al.
  Udgivet: (1999)
• Measurements of weak interactions between truncated substrates and a hammerhead ribozyme by competitive kinetic analyses: implications for the design of new and efficient ribozymes with high sequence specificity
  af: Kasai, Yasuhiro, et al.
  Udgivet: (2002)
• Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNA.
  af: Kuwabara, T, et al.
  Udgivet: (1997)
• A further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme
  af: Yoshinari, Koichi, et al.
  Udgivet: (2000)