Tumor promoter PMA stimulates the synthesis and secretion of mouse pro-urokinase in MSV-transformed 3T3 cells: this is mediated by an increase in urokinase mRNA content.

In mouse MSV-3T3 cells the synthesis of the urokinase form of plasminogen activator was increased 10-fold after addition of the tumor promoter phorbol-12-myristate-13-acetate (PMA). PMA also stimulated the secretion of the protein into the culture medium, mostly in the form of enzymatically inactive...

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Hauptverfasser: Belin, D, Godeau, F, Vassalli, J D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1984
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC557615/
https://ncbi.nlm.nih.gov/pubmed/6541126
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