Tumor promoter PMA stimulates the synthesis and secretion of mouse pro-urokinase in MSV-transformed 3T3 cells: this is mediated by an increase in urokinase mRNA content.

In mouse MSV-3T3 cells the synthesis of the urokinase form of plasminogen activator was increased 10-fold after addition of the tumor promoter phorbol-12-myristate-13-acetate (PMA). PMA also stimulated the secretion of the protein into the culture medium, mostly in the form of enzymatically inactive...

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Detalles Bibliográficos
Publicado en:EMBO J
Main Authors: Belin, D, Godeau, F, Vassalli, J D
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1984
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC557615/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6541126/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1984.tb02065.x
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