EGFR copy number alterations in primary tumors, metastatic lymph nodes, and recurrent and multiple primary tumors in oral cavity squamous cell carcinoma

BACKGROUND: The EGFR and downstream signaling pathways play an important role in tumorigenesis in oral squamous cell carcinoma (OSCC). Gene copy number alteration is one mechanism for overexpressing the EGFR protein and was also demonstrated to be related to lymph node metastasis, tumor invasiveness...

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Detalles Bibliográficos
Publicado en:BMC Cancer
Main Authors: Huang, Shiang-Fu, Chien, Huei-Tzu, Cheng, Sou-De, Chuang, Wen-Yu, Liao, Chun-Ta, Wang, Hung-Ming
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576106/
https://ncbi.nlm.nih.gov/pubmed/28854970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3586-9
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