Identification of cis-regulatory mutations generating de novo edges in personalized cancer gene regulatory networks

The identification of functional non-coding mutations is a key challenge in the field of genomics. Here we introduce μ-cisTarget to filter, annotate and prioritize cis-regulatory mutations based on their putative effect on the underlying “personal” gene regulatory network. We validated μ-cisTarget b...

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Enregistré dans:
Détails bibliographiques
Publié dans:Genome Med
Auteurs principaux: Kalender Atak, Zeynep, Imrichova, Hana, Svetlichnyy, Dmitry, Hulselmans, Gert, Christiaens, Valerie, Reumers, Joke, Ceulemans, Hugo, Aerts, Stein
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Method
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575942/
https://ncbi.nlm.nih.gov/pubmed/28854983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-017-0464-7
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