Isolation of type I and II DNA topoisomerase mutants from fission yeast: single and double mutants show different phenotypes in cell growth and chromatin organization.

We have isolated mutants defective in DNA topoisomerases and an endonuclease from the fission yeast Schizosaccharomyces pombe by screening individual extracts of mutagenized cells. Two type I topoisomerase mutants (top1) and three endonuclease mutants (end1) were all viable. The double mutant top1 e...

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Autores principales: Uemura, T, Yanagida, M
Formato: Artigo
Lenguaje:Inglês
Publicado: 1984
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC557590/
https://ncbi.nlm.nih.gov/pubmed/6090122
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