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Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated mitosis

The fission yeast top2 locus is defined by five temperature-sensitive mutations that cause heat-labile activity of type II DNA topoisomerase in the cell extracts. We show that the top2 locus is a structural gene for type II toposiomerase by cloning a genomic DNA fragment that complements top2. The t...

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Detalhes bibliográficos
Main Authors: Uemura, Tadashi, Yanagida, Mitsuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: 1986
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1166894/
https://ncbi.nlm.nih.gov/pubmed/15957215
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