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Studying the Conformation of a Receptor Tyrosine Kinase in Solution by Inhibitor‐Based Spin Labeling
The synthesis of a spin label based on PD168393, a covalent inhibitor of a major anticancer drug target, the epidermal growth factor receptor (EGFR), is reported. The label facilitates the analysis of the EGFR structure in solution by pulsed electron paramagnetic resonance (EPR) spectroscopy. For va...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5575716/ https://ncbi.nlm.nih.gov/pubmed/28628261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201703154 |
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