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Understanding Resistance Mechanisms and Expanding the Therapeutic Utility of PARP Inhibitors
Poly-(ADP-ribose) polymerase (PARP) inhibitors act through synthetic lethality in cells with defects in homologous recombination (HR) DNA repair caused by molecular aberrations such as BRCA mutations, and is approved for treatment in ovarian cancer, with promising clinical activity against other HR...
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| Publicado no: | Cancers (Basel) |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5575612/ https://ncbi.nlm.nih.gov/pubmed/28829366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers9080109 |
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