Peptide SS-31 upregulates frataxin expression and improves the quality of mitochondria: implications in the treatment of Friedreich ataxia

Friedreich ataxia is a progressive neurodegenerative disease caused by the expansion of GAA trinucleotide repeats within the first intron of the FXN gene, which encodes frataxin. The pathophysiology of the disease is thought to be derived from the decrease of Fe-S cluster biogenesis due to frataxin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhao, Hongting, Li, Huihui, Hao, Shuangying, Chen, Jiping, Wu, Jing, Song, Chuanhui, Zhang, Meng, Qiao, Tong, Li, Kuanyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575096/
https://ncbi.nlm.nih.gov/pubmed/28852135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10320-2
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