Antibody to mannose 6-phosphate specific receptor induces receptor deficiency in human fibroblasts.

Polyclonal antibodies to the mannose 6-phosphate specific receptor from human liver inhibited the endocytosis of lysosomal enzymes in fibroblasts by greater than 95% and enhanced 3-20-fold the secretion of precursors of lysosomal enzymes in these cells. Exposing fibroblasts for 4 h to antibody resul...

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Pubblicato in:	EMBO J
Autori principali:	von Figura, K, Gieselmann, V, Hasilik, A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1984
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC557509/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6086314/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1984.tb01963.x
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