Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration

Type 2 diabetes (T2D) is a disease characterized by impaired insulin secretion. The Wnt signaling transcription factor Tcf7l2 is to date the T2D-associated gene with the largest effect on disease susceptibility. However, the mechanisms by which TCF7L2 variants affect insulin release from β-cells are...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Facchinello, Nicola, Tarifeño-Saldivia, Estefania, Grisan, Enrico, Schiavone, Marco, Peron, Margherita, Mongera, Alessandro, Ek, Olivier, Schmitner, Nicole, Meyer, Dirk, Peers, Bernard, Tiso, Natascia, Argenton, Francesco
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575064/
https://ncbi.nlm.nih.gov/pubmed/28851992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09867-x
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