A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling

BPIFB4 is associated with exceptional longevity: four single-nucleotide polymorphisms distinguish the wild-type form from a longevity-associated variant conferring positive effects on blood pressure. The effect of a rare variant (RV; allele frequency, 4%) on blood pressure is unknown. Here, we show...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Vecchione, Carmine, Villa, Francesco, Carrizzo, Albino, Spinelli, Chiara Carmela, Damato, Antonio, Ambrosio, Mariateresa, Ferrario, Anna, Madonna, Michele, Uccellatore, Annachiara, Lupini, Silvia, Maciag, Anna, Ryskalin, Larisa, Milanesi, Luciano, Frati, Giacomo, Sciarretta, Sebastiano, Bellazzi, Riccardo, Genovese, Stefano, Ceriello, Antonio, Auricchio, Alberto, Malovini, Alberto, Puca, Annibale Alessandro
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574984/
https://ncbi.nlm.nih.gov/pubmed/28852218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10341-x
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia