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The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G.

When cisplatin [cis- diamminodichloroplatinum (II)] is diffused into pre-grown crystals of the B-DNA double-helical dodecamer C-G-C-G-A-A-T-T-C-G-C-G, it binds preferentially to the N7 positions of guanines, with what probably is an aquo bridge between Pt and the adjacent O6 atom of the same guanine...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EMBO J
Egile Nagusiak: Wing, R M, Pjura, P, Drew, H R, Dickerson, R E
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 1984
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC557495/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6539674/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1984.tb01951.x
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