The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G.

When cisplatin [cis- diamminodichloroplatinum (II)] is diffused into pre-grown crystals of the B-DNA double-helical dodecamer C-G-C-G-A-A-T-T-C-G-C-G, it binds preferentially to the N7 positions of guanines, with what probably is an aquo bridge between Pt and the adjacent O6 atom of the same guanine...

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Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Wing, R M, Pjura, P, Drew, H R, Dickerson, R E
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 1984
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC557495/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6539674/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1984.tb01951.x
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