No evidence for a direct role of HLA-B27 in pathological bone formation in axial SpA

OBJECTIVE: The strong genetic association between HLA-B27 and ankylosing spondylitis has been known for over 40 years. HLA-B27 positivity is possibly associated with severity of ankylosis. We studied the in vitro and in vivo impact of HLA-B27 in models of chondrogenesis and osteogenesis. METHODS: Di...

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Detalhes bibliográficos
Publicado no:RMD Open
Main Authors: Neerinckx, Barbara, Kollnberger, Simon, Shaw, Jacqueline, Lories, Rik
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2017
Assuntos:
Spondyloarthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574451/
https://ncbi.nlm.nih.gov/pubmed/28879048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rmdopen-2017-000451
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