Mammalian ECD Protein Is a Novel Negative Regulator of the PERK Arm of the Unfolded Protein Response

Mammalian Ecdysoneless (ECD) is a highly conserved ortholog of the Drosophila Ecd gene product whose mutations impair the synthesis of Ecdysone and produce cell-autonomous survival defects, but the mechanisms by which ECD functions are largely unknown. Here we present evidence that ECD regulates the...

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Pubblicato in:Mol Cell Biol
Autori principali: Olou, Appolinaire A., Sarkar, Aniruddha, Bele, Aditya, Gurumurthy, C. B., Mir, Riyaz A., Ammons, Shalis A., Mirza, Sameer, Saleem, Irfana, Urano, Fumihiko, Band, Hamid, Band, Vimla
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574048/
https://ncbi.nlm.nih.gov/pubmed/28652267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00030-17
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