Biophysical characterization and modeling of human Ecdysoneless (ECD) protein supports a scaffolding function

The human homolog of Drosophila ecdysoneless protein (ECD) is a p53 binding protein that stabilizes and enhances p53 functions. Homozygous deletion of mouse Ecd is early embryonic lethal and Ecd deletion delays G(1)-S cell cycle progression. Importantly, ECD directly interacts with the Rb tumor supp...

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Publicado no:AIMS Biophys
Main Authors: Mir, Riyaz A., Lovelace, Jeff, Schafer, Nicholas P., Simone, Peter D., Kellezi, Admir, Kolar, Carol, Spagnol, Gaelle, Sorgen, Paul L., Band, Hamid, Band, Vimla, Borgstahl, Gloria E. O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421643/
https://ncbi.nlm.nih.gov/pubmed/28492064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3934/biophy.2016.1.195
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